Article
Correlation between trough plasma dabigatran concentrations and estimates of glomerular filtration rate based on creatinine and cystatin C.
Drugs in R&D - 1 Jun 2014
Chin Paul K L, Wright Daniel F B, Zhang Mei, Wallace Mary C, Roberts Rebecca L, Patterson David M, Jensen Berit P, Barclay Murray L, Begg Evan J
Abstract excerpt
AIMS: Dabigatran is largely cleared by renal excretion. Renal function is thus a major determinant of trough dabigatran concentrations, which correlate with the risk of thromboembolic and haemorrhagic outcomes. Current dabigatran dosing guidelines use the Cockcroft-Gault (CG) equation to gauge renal function, instead of contemporary equations including the Chronic Kidney Disease Epidemiology Collaboration...
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