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Article

Pleiotropic model of maintenance of quantitative genetic variation at mutation-selection balance.

Genetics - 1 May 2002

Zhang Xu-Sheng, Wang Jinliang, Hill William G

Abstract excerpt

A pleiotropic model of maintenance of quantitative genetic variation at mutation-selection balance is investigated. Mutations have effects on a metric trait and deleterious effects on fitness, for which a bivariate gamma distribution is assumed. Equations for calculating the strength of apparent stabilizing selection (V(s)) and the genetic variance maintained in segregating populations (V(G)) were derived. A...

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Identifiers

PMID: 12019255
DOI: 10.1093/genetics/161.1.419
PMCID: PMC1462112

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Source receipt: pubmed, retrieved 7 Sept 2026.

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