Article
Mutational Pleiotropy and the Strength of Stabilizing Selection Within and Between Functional Modules of Gene Expression.
Genetics - 1 Apr 2018
Collet Julie M, McGuigan Katrina, Allen Scott L, Chenoweth Stephen F, Blows Mark W
Abstract excerpt
Variational modules, sets of pleiotropically covarying traits, affect phenotypic evolution, and therefore are predicted to reflect functional modules, such that traits within a variational module also share a common function. Such an alignment of function and pleiotropy is expected to facilitate adaptation by reducing the deleterious effects of mutations, and by allowing coordinated evolution of functionally...
Topics
- Algorithms
- Animals
- Biological Evolution
- Drosophila
- Gene Expression
- Genetic Association Studies
- Genetic Pleiotropy
- Genetic Variation
- Models, Genetic
- Mutation
- Phenotype