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Article

Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases.

Cell death & disease - 1 May 2014

Farhat M, Poissonnier A, Hamze A, Ouk-Martin C, Brion J-D, Alami M, Feuillard J, Jayat-Vignoles C

Abstract excerpt

Defects in apoptosis are frequently the cause of cancer emergence, as well as cellular resistance to chemotherapy. These phenotypes may be due to mutations of the tumor suppressor TP53 gene. In this study, we examined the effect of various mitotic spindle poisons, including the new isocombretastatin derivative isoNH2CA-4 (a tubulin-destabilizing molecule, considered to bind to the colchicine site by analogy with...

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Identifiers

PMID: 24787013
DOI: 10.1038/cddis.2014.150
PMCID: PMC4047855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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