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Article

Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Oct 2014

Tsusaka Takeshi, Guo Tingting, Yagura Teiti, Inoue Toshiaki, Yokode Masayuki, Inagaki Nobuya, Kondoh Hiroshi

Abstract excerpt

Substantially high rate of glycolysis, known as the Warburg effect, is a well-known feature of cancers, and emerging evidence suggests that it supports cancerous proliferation/tumor growth. Phosphoglycerate mutase (PGAM), a glycolytic enzyme, is commonly up-regulated in several cancers, and recent reports show its involvement in the Warburg effect. Here, a comprehensive analysis shows that PGAM is acetylated at...

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Source

Identifiers

PMID: 25195573
DOI: 10.1111/gtc.12176

Genes

SIRT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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