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Article

Resveratrol inhibits collagen I synthesis by suppressing IGF-1R activation in intestinal fibroblasts.

World journal of gastroenterology - 28 Apr 2014

Li Ping, Liang Mei-Lan, Zhu Ying, Gong Yao-Yao, Wang Yun, Heng Ding, Lin Lin

Abstract excerpt

AIM: To investigate whether resveratrol (3,4,5-trihydroxy-trans-stilbene) inhibits collagen I synthesis induced by insulin growth factor-1 (IGF-1) in intestinal fibroblasts, and to explore the possible molecular mechanisms. METHODS: Male Sprague-Dawley rats were randomly divided into two groups: a control group and a 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis group. After 21 d of TNBS...

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Identifiers

PMID: 24782617
DOI: 10.3748/wjg.v20.i16.4648
PMCID: PMC4000501

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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