Article
Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes.
Molecular and cellular endocrinology - 5 Sept 2013
Yu An, Zheng Yu, Zhang Rongrong, Huang Jianfeng, Zhu Zhoujie, Zhou Ronghua, Jin Dan, Yang Zaiqing
Abstract excerpt
Resistin is a cysteine-rich secreted protein which significantly inhibits phosphorylation of AMP-activated protein kinase in both human and mouse hepatocytes. It has been demonstrated that resistin plays an important role in inducing hepatic insulin resistance. However, whether resistin has other unknown influences on hepatocytes still remains poorly studied. Here, we show that recombinant resistin protein...
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