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Article

SIRT-1 regulates TGF-β-induced dermal fibroblast migration via modulation of Cyr61 expression.

Connective tissue research - 1 May 2018

Kwon Eun-Jeong, Park Eun-Jung, Yu Hyeran, Huh Jung-Sik, Kim Jinseok, Cho Moonjae

Abstract excerpt

SIRT1 is a NAD-dependent protein deacetylase that participates in cellular regulation. The increased migration of fibroblasts is an important phenotype in fibroblast activation. The role of SIRT1 in cell migration remains controversial as to whether SIRT1 acts as an activator or suppressor of cell migration. Therefore, we have established the role of SIRT1 in the migration of human dermal fibroblasts and explored...

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Source

Identifiers

PMID: 28750181
DOI: 10.1080/03008207.2017.1360293

Genes

SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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