Article
Segregation of a QTL cluster for home-cage activity using a new mapping method based on regression analysis of congenic mouse strains.
Heredity - 1 Nov 2014
Kato S, Ishii A, Nishi A, Kuriki S, Koide T
Abstract excerpt
Recent genetic studies have shown that genetic loci with significant effects in whole-genome quantitative trait loci (QTL) analyses were lost or weakened in congenic strains. Characterisation of the genetic basis of this attenuated QTL effect is important to our understanding of the genetic mechanisms of complex traits. We previously found that a consomic strain, B6-Chr6C(MSM), which carries chromosome 6 of a...
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