Article
Alterations in cholesterol metabolism restrict HIV-1 trans infection in nonprogressors.
mBio - 29 Apr 2014
Rappocciolo Giovanna, Jais Mariel, Piazza Paolo, Reinhart Todd A, Berendam Stella J, Garcia-Exposito Laura, Gupta Phalguni, Rinaldo Charles R
Abstract excerpt
ABSTRACT HIV-1-infected nonprogressors (NP) inhibit disease progression for years without antiretroviral therapy. Defining the mechanisms for this resistance to disease progression could be important in determining strategies for controlling HIV-1 infection. Here we show that two types of professional antigen-presenting cells (APC), i.e., dendritic cells (DC) and B lymphocytes, from NP lacked the ability to...
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