Article
Modeling HIV transfer between dendritic cells and T cells: importance of HIV phenotype, dendritic cell-T cell contact and T-cell activation.
AIDS (London, England) - 20 Oct 2000
Vanham G, Penne L, Allemeersch H, Kestens L, Willems B, van der Groen G, Jeang K T, Toossi Z, Rich E
Abstract excerpt
OBJECTIVE: To study the requirements for HIV transfer between dendritic cells (DC) and CD4 T cells, using an in vitro model, combined with flow cytometry. METHODS: Immature DC and macrophages (MA) were generated from monocytes. After infection, DC or MA were cultured alone or with purified CD4 T cells. Intracellular HIV was measured, using (1) the monocyte (MO)-tropic AD8 HIV, endowed with enhanced green...
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