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Article

The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.

The Journal of clinical investigation - 1 Oct 2009

Arhel Nathalie, Lehmann Martin, Clauss Karen, Nienhaus G Ulrich, Piguet Vincent, Kirchhoff Frank

Abstract excerpt

Viruses that infect T cells, including those of the lentivirus genus, such as HIV-1, modulate the responsiveness of infected T cells to stimulation by interacting APCs in a manner that renders the T cells more permissive for viral replication. HIV-1 and other primate lentiviruses use their Nef proteins to manipulate the T cell/APC contact zone, the immunological synapse (IS). It is known that primate lentiviral...

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Source

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Identifiers

PMID: 19759518
DOI: 10.1172/JCI38994
PMCID: PMC2752074

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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