Article
Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL.
Blood - 14 Aug 2014
Wang Lili, Shalek Alex K, Lawrence Mike, Ding Ruihua, Gaublomme Jellert T, Pochet Nathalie, Stojanov Petar, Sougnez Carrie, Shukla Sachet A, Stevenson Kristen E, Zhang Wandi, Wong Jessica, Sievers Quinlan L, MacDonald Bryan T, Vartanov Alexander R, Goldstein Natalie R, Neuberg Donna, He Xi, Lander Eric, Hacohen Nir, Regev Aviv, Getz Gad, Brown Jennifer R, Park Hongkun, Wu Catherine J
Abstract excerpt
One major goal of cancer genome sequencing is to identify key genes and pathways that drive tumor pathogenesis. Although many studies have identified candidate driver genes based on recurrence of mutations in individual genes, subsets of genes with nonrecurrent mutations may also be defined as pu...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.