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Article

Clinicopathological features and prognostic roles of KRAS, BRAF, PIK3CA and NRAS mutations in advanced gastric cancer.

BMC research notes - 29 Apr 2014

Takahashi Naoki, Yamada Yasuhide, Taniguchi Hirokazu, Fukahori Masaru, Sasaki Yusuke, Shoji Hirokazu, Honma Yoshitaka, Iwasa Satoru, Takashima Atsuo, Kato Ken, Hamaguchi Tetsuya, Shimada Yasuhiro

Abstract excerpt

BACKGROUND: RAS-RAF-MEK-ERK and PI3K-AKT pathways form a significant cascade for potential molecular target therapy in advanced cancer. The clinical significance of mutations in these genes in advanced gastric cancer (AGC) is uncertain. METHODS: We collected formalin-fixed, paraffin-embedded and fresh frozen tumor samples from AGC patients and analyzed the KRAS, NRAS, BRAF and PIK3CA mutations by...

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Identifiers

PMID: 24774510
DOI: 10.1186/1756-0500-7-271
PMCID: PMC4012089

Genes

NRAS
KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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