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Article

New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acid.

PloS one - 1 Jan 2014

Uchiyama Kazuhiko, Takagi Tomohisa, Iwamoto Yasunori, Kondo Norihiko, Okayama Tetsuya, Yoshida Naohisa, Kamada Kazuhiro, Katada Kazuhiro, Handa Osamu, Ishikawa Takeshi, Yasuda Hiroaki, Sakagami Junichi, Konishi Hideyuki, Yagi Nobuaki, Naito Yuji, Itoh Yoshito

Abstract excerpt

BACKGROUND AND AIMS: Azathioprine (AZA) is widely used for the treatment of inflammatory bowel disease (IBD) patients. AZA is catabolized by thiopurine S-methyltransferase (TPMT), which exhibits genetic polymorphisms. It has also been reported that 5-aminosalicylic acid (5-ASA) inhibits TPMT activity, and that increased 6-thioguanine nucleotide (6-TGN, a metabolite of AZA) blood concentrations result in an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24762746
DOI: 10.1371/journal.pone.0095080
PMCID: PMC3999094

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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