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Molecular network analysis suggests aberrant CREB-mediated gene regulation in the Alzheimer disease hippocampus.

1 Jan 2009

Abstract excerpt

The pathogenesis of Alzheimer disease (AD) involves the complex interaction between genetic and environmental factors affecting multiple cellular pathways. Recent advances in systems biology provide a system-level understanding of AD by elucidating the genome-wide molecular interactions. By using KeyMolnet, a bioinformatics tool for analyzing molecular interactions on the curated knowledgebase, we characterized...

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PMID: 20037212
DOI: 10.3233/dma-2009-0670

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