Article
Contribution of functional LILRA3, but not nonfunctional LILRA3, to sex bias in susceptibility and severity of anti-citrullinated protein antibody-positive rheumatoid arthritis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Apr 2014
Du Yan, Cui Yong, Liu Xia, Hu Fanlei, Yang Yue, Wu Xinyu, Liu Xu, Ma Xiaoxu, Zuo Xianbo, Sheng Yujun, Liu Xiangyuan, Xu Jianhua, Zhu Ping, Sun Lingyun, Hong Nan, Zhang Xuejun, Guo Jianping, Li Zhanguo
Abstract excerpt
OBJECTIVE: Leukocyte immunoglobulin-like receptor A3 belongs to a family of receptors with inhibitory or activating functions. Since Caucasian individuals lacking LILRA3 have been found to be susceptible to multiple sclerosis and Sjögren's syndrome, we undertook this study to examine whether LILRA3 deletion is a novel genetic risk factor for rheumatoid arthritis (RA) (another autoimmune disease), whether there...
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