Allosteric Inhibition of the Hepatitis C Virus NS5B Polymerase: <i>In Silico</i> Strategies for Drug Discovery and Development

Abstract excerpt

Chronic infection by hepatitis C virus (HCV) often leads to severe liver disease including cirrhosis, hepatocellular carcinoma and liver failure. Despite it being more than 20 years since the identification of HCV, the current standard of care for treating the infection is based on aspecific therapy often associated with severe side effects and low-sustained virological response. Research is ongoing to develop...

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