SDHB mutations are associated with response to temozolomide in patients with metastatic pheochromocytoma or paraganglioma.

doi:10.1002/ijc.28913

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Article

SDHB mutations are associated with response to temozolomide in patients with metastatic pheochromocytoma or paraganglioma.

International journal of cancer - 1 Dec 2014

Hadoux Julien, Favier Judith, Scoazec Jean-Yves, Leboulleux Sophie, Al Ghuzlan Abir, Caramella Caroline, Déandreis Désirée, Borget Isabelle, Loriot Céline, Chougnet Cécile, Letouzé Eric, Young Jacques, Amar Laurence, Bertherat Jérome, Libé Rosella, Dumont Frédéric, Deschamps Frédéric, Schlumberger Martin, Gimenez-Roqueplo Anne Paule, Baudin Eric

Abstract excerpt

Cyclophosphamide-dacarbazine-vincristine regimen is recommended for the treatment of malignant pheochromocytoma and paraganglioma (MPP); however, dacarbazine is the only recognized active drug in neuroendocrine tumours. We investigated the therapeutic benefit of temozolomide (TMZ), an oral alternative to dacarbazine, in patients with MPP. This is a retrospective study of consecutive patients with documented...

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Identifiers

PMID: 24752622
DOI: 10.1002/ijc.28913

Genes

MGMT
SDHB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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