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Continued Tumor Reduction of Metastatic Pheochromocytoma/Paraganglioma Harboring Succinate Dehydrogenase Subunit B Mutations with Cyclical Chemotherapy.

Cellular and molecular neurobiology - 1 Jul 2018

Jawed Irfan, Velarde Margarita, Därr Roland, Wolf Katherine I, Adams Karen, Venkatesan Aradhana M, Balasubramaniam Sanjeeve, Poruchynsky Marianne S, Reynolds James C, Pacak Karel, Fojo Tito

Abstract excerpt

Patients harboring germline mutations in the succinate dehydrogenase complex subunit B (SDHB) gene present with pheochromocytomas and paragangliomas (PPGL) that are more likely malignant and clinically aggressive. The combination chemotherapy cyclophosphamide, vincristine, and dacarbazine (CVD) was retrospectively evaluated in patients with SDHB-associated metastatic PPGL.Query Twelve metastatic PPGL patients...

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Identifiers

PMID: 29623478
DOI: 10.1007/s10571-018-0579-4
PMCID: PMC5976545

Genes

SDHB

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Continued Tumor Reduction of Metastatic Pheochromocytoma/Paraganglioma Harboring Succinate Dehydrogenase Subunit B Mutations with Cyclical Chemotherapy.PMID 29623478Read ↗

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