Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.

doi:10.1038/ng.2949

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Article

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.

Nature genetics - 1 Jun 2014

Lane Andrew A, Chapuy Bjoern, Lin Charles Y, Tivey Trevor, Li Hubo, Townsend Elizabeth C, van Bodegom Diederik, Day Tovah A, Wu Shuo-Chieh, Liu Huiyun, Yoda Akinori, Alexe Gabriela, Schinzel Anna C, Sullivan Timothy J, Malinge Sébastien, Taylor Jordan E, Stegmaier Kimberly, Jaffe Jacob D, Bustin Michael, te Kronnie Geertruy, Izraeli Shai, Harris Marian H, Stevenson Kristen E, Neuberg Donna, Silverman Lewis B, Sallan Stephen E, Bradner James E, Hahn William C, Crispino John D, Pellman David, Weinstock David M

Abstract excerpt

Down syndrome confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (B-ALL), and polysomy 21 is the most frequent somatic aneuploidy among all B-ALLs. Yet the mechanistic links between chromosome 21 triplication and B-ALL remain undefined. Here we show that germline triplication...

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Identifiers

PMID: 24747640
DOI: 10.1038/ng.2949
PMCID: PMC4040006

Genes

HMGN1
BCR
CRLF2
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24747640-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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