Article
Homeostatic epithelial renewal in the gut is required for dampening a fatal systemic wound response in Drosophila.
Cell reports - 28 Mar 2013
Takeishi Asuka, Kuranaga Erina, Tonoki Ayako, Misaki Kazuyo, Yonemura Shigenobu, Kanuka Hirotaka, Miura Masayuki
Abstract excerpt
Effective defense responses involve the entire organism. To maintain body homeostasis after tissue damage, a systemic wound response is induced in which the response of each tissue is tightly orchestrated to avoid incomplete recovery or an excessive, damaging response. Here, we provide evidence that in the systemic response to wounding, an apoptotic caspase pathway is activated downstream of reactive oxygen...
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