Article
Expression of indoleamine 2,3-dioxygenase and infiltration of FOXP3+ regulatory T cells are associated with aggressive features of papillary thyroid microcarcinoma.
Thyroid : official journal of the American Thyroid Association - 1 Aug 2014
Ryu Han Suk, Park Young Soo, Park Hyo Jin, Chung Yul Ri, Yom Cha Kyong, Ahn Soon-Hyun, Park Young Joo, Park Seong Hoe, Park So Yeon
Abstract excerpt
BACKGROUND: Indoleamine 2,3-dioxygenase (IDO) is overexpressed in many different types of tumor and is associated with activation of FOXP3+ regulatory T cells (Treg cells) and downregulation of cytotoxic cellular immunity in the tumor microenvironment. It has been suggested that IDO inhibitors can be utilized as an effective therapeutic agent against human cancers. However, the expression of IDO and its...
Topics
- Adult
- Aged
- CD3 Complex
- CD8-Positive T-Lymphocytes
- Carcinoma, Papillary
- Disease Progression
- Female
- Forkhead Transcription Factors
- Humans
- Immunity, Cellular
- Immunohistochemistry
- Indoleamine-Pyrrole 2,3,-Dioxygenase