Article
Whole blood thrombin generation in Bmal1-deficient mice.
Thrombosis and haemostasis - 1 Aug 2014
Ninivaggi M, Kelchtermans H, Kuijpers M J, Hemmeryckx B, Heemskerk J W M, Lindhout T, Hoylaerts M F, de Laat B
Abstract excerpt
The Calibrated Automated Thrombogram (CAT) assay that measures thrombin generation (TG) in platelet-poor and -rich plasma, is increasingly being recognised as a more sensitive tool to determine the overall function of the haemostatic system. We developed a method enabling the measurement of TG in a small aliquot of blood. The objective was to validate this assay in mouse blood and to examine the rate and extent...
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