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Article

Estimation of Interindividual Variability of Pharmacokinetics of CYP2C9 Substrates in Humans.

Journal of pharmaceutical sciences - 1 Sept 2017

Chiba Koji, Shimizu Keiko, Kato Motohiro, Miyazaki Taichi, Nishibayashi Takaaki, Terada Kazuki, Sugiyama Yuichi

Abstract excerpt

The activity of metabolic enzymes varies across individuals and populations. Activity varies even among individuals sharing the same genotype. Genetic polymorphisms in CYP2C9 cause significant interindividual variability in the metabolism of its substrates. However, the variability of CYP2C9 intrinsic hepatic clearance (CLint,h,CYP2C9) among subjects of the same genotype has not been reported. In this study, we...

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Identifiers

PMID: 28435143
DOI: 10.1016/j.xphs.2017.04.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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