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Article

Transcriptional dissection of pancreatic tumors engrafted in mice

16 Apr 2014

Abstract excerpt

BACKGROUND: Engraftment of primary pancreas ductal adenocarcinomas (PDAC) in mice to generate patient-derived xenograft (PDX) models is a promising platform for biological and therapeutic studies in this disease. However, these models are still incompletely characterized. Here, we measured the impact of the murine tumor environment on the gene expression of the engrafted human tumoral cells. METHODS: We have...

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PMID: 24739241
DOI: 10.1186/gm544

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