Article
Longitudinal identification of clinically distinct neurophenotypes in young children with fragile X syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 3 Oct 2017
Bruno Jennifer L, Romano David, Mazaika Paul, Lightbody Amy A, Hazlett Heather Cody, Piven Joseph, Reiss Allan L
Abstract excerpt
Fragile X syndrome (FXS), due to mutations of the FMR1 gene, is the most common known inherited cause of developmental disability. The cognitive, behavioral, and neurological phenotypes observed in affected individuals can vary considerably, making it difficult to predict outcomes and determine the need for interventions. We sought to examine early structural brain growth as a potential marker for identification...
Topics
- Brain
- Child Development
- Child, Preschool
- Cognition
- Female
- Fragile X Syndrome
- Humans
- Image Processing, Computer-Assisted
- Longitudinal Studies
- Magnetic Resonance Imaging
- Male
- Neuropsychological Tests
- Phenotype