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Article

BRCA1 and BRCA2 germline mutations are frequently demonstrated in both high-risk pancreatic cancer screening and pancreatic cancer cohorts.

Cancer - 1 Jul 2014

Lucas Aimee L, Frado Laura E, Hwang Caroline, Kumar Sheila, Khanna Lauren G, Levinson Elana J, Chabot John A, Chung Wendy K, Frucht Harold

Abstract excerpt

BACKGROUND: Approximately 10% of pancreatic ductal adenocarcinoma (PDAC) is due to a genetic predisposition, including the breast and ovarian cancer syndrome germline mutations BRCA1 and BRCA2. Knowledge of specific genetic mutations predisposing to PDAC may enable risk stratification, early detection, and the development of effective screening and surveillance programs. In the current study, the authors...

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Source

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Identifiers

PMID: 24737347
DOI: 10.1002/cncr.28662
PMCID: PMC5494829

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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