Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review.

Molecular medicine reports - 1 Aug 2018

Pang Minghui, Liu Yijun, Hou Xiaolin, Yang Jialiang, He Xuelai, Hou Nengyi, Liu Peixi, Liang Luo, Fu Junwen, Wang Kang, Ye Zimeng, Gong Bo

Abstract excerpt

Familial adenomatous polyposis (FAP), an autosomal dominant disease, is a colon cancer predisposition syndrome that manifests as a large number of adenomatous polyps. Mutations in the Adenomatous polyposis coli (APC) gene are responsible for the majority of cases of FAP. The purpose of the present study was to report the clinical features of a Chinese family with FAP and screen for novel mutations using the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli
Share to Adenomatous Polyposis Coli Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Frameshift Mutation

Share to Gene Expression

Share to High-Throughput Nucleotide Sequencing

Share to Models, Molecular

Share to Protein Structure, Secondary

Source

Open in PubMed Open full text

Identifiers

PMID: 29901124
DOI: 10.3892/mmr.2018.9130
PMCID: PMC6072187

Genes

FAP
APC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review.PMID 29901124Read ↗

Novel and reported APC germline mutations in Chinese patients with familial adenomatous polyposis.Semantic proximity Read ↗

Three novel mutations of APC gene in Chinese patients with familial adenomatous polyposis.Semantic proximity Read ↗

A novel pathogenic single nucleotide germline deletion in APC gene in a four generation Chinese family with familial adenomatous polyposis.Semantic proximity Read ↗

Mutational screening through comprehensive bioinformatics analysis to detect novel germline mutations in the APC gene in patients with familial adenomatous polyposis (FAP).Semantic proximity Read ↗

Clinical characteristics and APC gene mutation spectrum of familial adenomatous polyposis patients in ChinaSemantic proximity Read ↗

Mutational Analysis of a Familial Adenomatous Polyposis Pedigree with Bile Duct Polyp Phenotype.Semantic proximity Read ↗

An update of the variant spectrum of the APC gene in Iranian familial adenomatous polyposis patients.Semantic proximity Read ↗

Two Chinese pedigrees for adenomatous polyposis coli: new mutations at codon 1309 and predisposition to phenotypic variations.Semantic proximity Read ↗

Mutation analysis of the APC gene in unrelated Korean patients with FAP: four novel mutations with unusual phenotype.Semantic proximity Read ↗

[Analysis of clinical features and genetic variant in a Chinese pedigree affected with familial adenomatous polyposis].Semantic proximity Read ↗

Novel insertion mutation p.Asp610GlyfsX23 in APC gene causes familial adenomatous polyposis in Chinese families.Semantic proximity Read ↗

Analysis of Small Fragment Deletions of the APC gene in Chinese Patients with Familial Adenomatous Polyposis, a Precancerous Condition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.