Article
An update of the variant spectrum of the APC gene in Iranian familial adenomatous polyposis patients.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2024
Mirabdolhosseini Seyed Mohsen, Rejali Leili, Yaghoob Taleghani Mohammad, Sadeghi Hossein, Kashfi Seyed Mohammad Hossein, Behboudi Farahbakhsh Faeghe, Golmohammadi Mina, Larki Pegah, Fatemi Nayeralsadat, Ketabi Moghadam Pardis, Nazemalhosseini Mojarad Ehsan, Sadeghi Amir, Asadzadeh Aghdaie Hamid, Zali Mohammad Reza
Abstract excerpt
Familial adenomatous polyposis (FAP) is an autosomal dominant colorectal cancer syndrome that is characterized by the development of multiple adenomas in the colon and rectum with high penetrance rates. This disease has specific features like the occurrence of pathogenic variations in the APC gene and diverse FAP phenotypes due to the occurrence region. In this study we aimed to evaluate pathogenic variants in...
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