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Article

Association of RANK and RANKL gene polymorphism with survival and calcium levels in multiple myeloma.

Molecular carcinogenesis - 1 Feb 2021

Łacina Piotr, Butrym Aleksandra, Humiński Michał, Dratwa Marta, Frontkiewicz Diana, Mazur Grzegorz, Bogunia-Kubik Katarzyna

Abstract excerpt

Multiple myeloma (MM) is a heterogeneous bone marrow cancer characterized by proliferation of malignant plasma cells in the bone marrow. One of its major symptoms are hypercalcaemia and bone lesions, which may result in pathologic bone fractures. Receptor activator for nuclear factor κB (RANK) and its ligand, RANKL, are part of an activation pathway for osteoclasts and are thus responsible for bone resorption....

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PMID: 33283899
DOI: 10.1002/mc.23272

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