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Article

LMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells.

The Journal of biological chemistry - 23 May 2014

Luz Simão, Cihil Kristine M, Brautigan David L, Amaral Margarida D, Farinha Carlos M, Swiatecka-Urban Agnieszka

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl(-)-selective ion channel expressed in fluid-transporting epithelia. Lemur tyrosine kinase 2 (LMTK2) is a transmembrane protein with serine and threonine but not tyrosine kinase activity. Previous work identified CFTR as an in vitro substrate of LMTK2, suggesting a functional link. Here we demonstrate that LMTK2 co-immunoprecipitates with CFTR and...

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Source

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Identifiers

PMID: 24727471
DOI: 10.1074/jbc.M114.563742
PMCID: PMC4031558

Genes

CFTR
LMTK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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