Article
A mutation in the cystic fibrosis transmembrane conductance regulator generates a novel internalization sequence and enhances endocytic rates.
The Journal of biological chemistry - 28 Mar 2003
Silvis Mark R, Picciano John A, Bertrand Carol, Weixel Kelly, Bridges Robert J, Bradbury Neil A
Abstract excerpt
Cystic fibrosis is a common lethal genetic disease among Caucasians. The cystic fibrosis gene encodes a cyclic adenosine monophosphate-activated chloride channel (cystic fibrosis transmembrane conductance regulator (CFTR)) that mediates electrolyte transport across the luminal surfaces of a variety of epithelial cells. Mutations in CFTR fall into two broad categories; those that affect protein...
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