Article
Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity.
Molecular and cellular biology - 1 Nov 2011
Luz Simão, Kongsuphol Patthara, Mendes Ana Isabel, Romeiras Francisco, Sousa Marisa, Schreiber Rainer, Matos Paulo, Jordan Peter, Mehta Anil, Amaral Margarida D, Kunzelmann Karl, Farinha Carlos M
Abstract excerpt
Previously, the pleiotropic "master kinase" casein kinase 2 (CK2) was shown to interact with CFTR, the protein responsible for cystic fibrosis (CF). Moreover, CK2 inhibition abolished CFTR conductance in cell-attached membrane patches, native epithelial ducts, and Xenopus oocytes. CFTR possesses two CK2 phosphorylation sites (S422 and T1471), with unclear impact on its processing and trafficking. Here, we...
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