Article
Identification of a phosphate regulatory site and a low affinity binding site for glucose 6-phosphate in the N-terminal half of human brain hexokinase.
The Journal of biological chemistry - 31 Jul 1998
Fang T Y, Alechina O, Aleshin A E, Fromm H J, Honzatko R B
Abstract excerpt
Crystal structures of human hexokinase I reveal identical binding sites for phosphate and the 6-phosphoryl group of glucose 6-phosphate in proximity to Gly87, Ser88, Thr232, and Ser415, a binding site for the pyranose moiety of glucose 6-phosphate in proximity to Asp84, Asp413, and Ser449, and a...
Topics
- Binding Sites
- Brain
- Circular Dichroism
- Enzyme Inhibitors
- Glucose-6-Phosphate
- Hexokinase
- Humans
- Kinetics
- Models, Molecular
- Mutation
- Phosphates
- Protein Binding
- Protein Structure, Secondary