Article
Binding of glutathione to enterovirus capsids is essential for virion morphogenesis.
PLoS pathogens - 1 Apr 2014
Thibaut Hendrik Jan, van der Linden Lonneke, Jiang Ping, Thys Bert, Canela María-Dolores, Aguado Leire, Rombaut Bart, Wimmer Eckard, Paul Aniko, Pérez-Pérez María-Jesús, van Kuppeveld Frank J M, Neyts Johan
Abstract excerpt
Enteroviruses (family of the Picornaviridae) cover a large group of medically important human pathogens for which no antiviral treatment is approved. Although these viruses have been extensively studied, some aspects of the viral life cycle, in particular morphogenesis, are yet poorly understood. We report the discovery of TP219 as a novel inhibitor of the replication of several enteroviruses, including...
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