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Article

Human Viperin Causes Radical SAM-Dependent Elongation of Escherichia coli, Hinting at Its Physiological Role.

Biochemistry - 1 Aug 2017

Nelp Micah T, Young Anthony P, Stepanski Branden M, Bandarian Vahe

Abstract excerpt

Viperin (virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) is a widely distributed protein that is expressed in response to infection and causes antiviral effects against a broad spectrum of viruses. Viperin is a member of the radical S-adenosyl-l-methionine (SAM) superfamily of enzymes, which typically employ a 4Fe-4S cluster to reductively cleave SAM to initiate chemistry. Though...

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PMID: 28708394
DOI: 10.1021/acs.biochem.7b00608
PMCID: PMC6400073

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