Article
Heterogeneity of clonal expansion and maturation-linked mutation acquisition in hematopoietic progenitors in human acute myeloid leukemia.
Leukemia - 1 Oct 2014
Walter R B, Laszlo G S, Lionberger J M, Pollard J A, Harrington K H, Gudgeon C J, Othus M, Rafii S, Meshinchi S, Appelbaum F R, Bernstein I D
Abstract excerpt
Recent technological advances led to an appreciation of the genetic complexity of human acute myeloid leukemia (AML), but underlying progenitor cells remain poorly understood because their rarity precludes direct study. We developed a co-culture method integrating hypoxia, aryl hydrocarbon receptor inhibition and micro-environmental support via human endothelial cells to isolate these cells. X-chromosome...
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