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Article

Endothelial progenitor cells are clonal and exhibit the JAK2(V617F) mutation in a subset of thrombotic patients with Ph-negative myeloproliferative neoplasms.

Blood - 3 Mar 2011

Teofili Luciana, Martini Maurizio, Iachininoto Maria Grazia, Capodimonti Sara, Nuzzolo Eugenia Rosa, Torti Lorenza, Cenci Tonia, Larocca Luigi Maria, Leone Giuseppe

Abstract excerpt

In this study we investigated whether neoplastic transformation occurring in Philadelphia (Ph)-negative myeloproliferative neoplasms (MPNs) could involve also the endothelial cell compartment. We evaluated the level of endothelial colony-forming cells (E-CFCs) in 42 patients (15 with polycythemia vera, 12 with essential thrombocythemia, and 15 with primary myelofibrosis). All patients had 1 molecular abnormality...

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Source

Identifiers

PMID: 21212285
DOI: 10.1182/blood-2010-07-297598

Genes

JAK2
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Endothelial progenitor cells are clonal and exhibit the JAK2(V617F) mutation in a subset of thrombotic patients with Ph-negative myeloproliferative neoplasms.PMID 21212285Read ↗

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The possible role of mutated endothelial cells in myeloproliferative neoplasms.Semantic proximity Read ↗

A murine model with JAK2V617F expression in both hematopoietic cells and vascular endothelial cells recapitulates the key features of human myeloproliferative neoplasmSemantic proximity Read ↗

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JAK2V <sub>617</sub> F-positive endothelial cells contribute to clotting abnormalities in myeloproliferative neoplasmsSemantic proximity Read ↗

The impact of JAK2V617F mutation on Philadelphia-negative myeloproliferative neoplasms.Semantic proximity Read ↗

Clonal analyses define the relationships between chromosomal abnormalities and JAK2V617F in patients with Ph-negative myeloproliferative neoplasms.Semantic proximity Read ↗

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