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Article

ERK Activity in Immature Leukemic Cells Drives Clonal Selection during Induction Therapy for Acute Myeloid Leukemia.

Scientific reports - 20 May 2020

Hayun Michal, Zaatra Maria, Itzkovich Chen, Sahar Dvora, Rosenberg Dina, Filatova Margarita, Ringelstein-Harlev Shimrit, Baris Hagit, Moustafa-Hawash Nivin, Louria-Hayon Igal, Ofran Yishai

Abstract excerpt

Selection of resistant clones following intensive chemotherapy is a common obstacle for cure in many cancers, particularly in acute myeloid leukemia (AML). In AML, clone-specific sensitivity to chemotherapy varies even within the same patient. Multiple mutations and genetic aberrations are associated with clones surviving chemotherapy. The current study explored the role of activated signaling pathways in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32433559
DOI: 10.1038/s41598-020-65061-6
PMCID: PMC7239856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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