Article
Critical transition in tissue homeostasis accompanies murine lung senescence.
PloS one - 1 Jan 2011
Calvi Carla L, Podowski Megan, D'Alessio Franco R, Metzger Shana L, Misono Kaori, Poonyagariyagorn Hataya, Lopez-Mercado Armando, Ku Therese, Lauer Thomas, Cheadle Christopher, Talbot C Conover, Jie Chunfa, McGrath-Morrow Sharon, King Landon S, Walston Jeremy, Neptune Enid R
Abstract excerpt
BACKGROUND: Respiratory dysfunction is a major contributor to morbidity and mortality in aged populations. The susceptibility to pulmonary insults is attributed to "low pulmonary reserve", ostensibly reflecting a combination of age-related musculoskeletal, immunologic and intrinsic pulmonary dysfunction. METHODS/PRINCIPAL FINDINGS: Using a murine model of the aging lung, senescent DBA/2 mice, we correlated a...
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