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Article

A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation.

Biochimica et biophysica acta - 1 Jul 2014

Osborne Brenna, Yao Tsun-Wen, Wang Xin Maggie, Chen Yiqian, Kotan L Damla, Nadvi Naveed A, Herdem Mustafa, McCaughan Geoffrey W, Allen John D, Yu Denise M T, Topaloglu A Kemal, Gorrell Mark D

Abstract excerpt

Fibroblast activation protein (FAP) is a focus of interest as a potential cancer therapy target. This membrane bound protease possesses the unique catalytic activity of hydrolysis of the post-proline bond two or more residues from the N-terminus of substrates. FAP is highly expressed in activated...

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Source

Identifiers

PMID: 24717288
DOI: 10.1016/j.bbapap.2014.03.015

Genes

FAP
ATF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24717288-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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