Article
Molecular genetic study of Finns with hypoalphalipoproteinemia and hyperalphalipoproteinemia: a novel Gly230 Arg mutation (LCAT[Fin]) of lecithin:cholesterol acyltransferase (LCAT) accounts for 5% of cases with very low serum HDL cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 1998
Miettinen H E, Gylling H, Tenhunen J, Virtamo J, Jauhiainen M, Huttunen J K, Kantola I, Miettinen T A, Kontula K
Abstract excerpt
In an attempt to identify genetic factors underlying extreme alterations of serum HDL cholesterol (HDL-C) concentrations, we examined two probands with HDL-C levels <0.2 mmol/L and subsequently screened two large cohorts of smoking men, one with very low (0.2 to 0.7 mmol/L, n=156) and the other w...
Topics
- Adult
- Arginine
- Carrier Proteins
- Cholesterol Ester Transfer Proteins
- Cholesterol Esters
- Cholesterol, HDL
- Cholesterol, LDL
- Finland
- Glycine
- Glycoproteins
- Humans
- Hyperlipoproteinemias
- Male