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Article

Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen-Bound BTN3A1.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2023

Nguyen Khiem, Jin Yiming, Howell Matthew, Hsiao Chia-Hung Christine, Wiemer Andrew J, Vinogradova Olga

Abstract excerpt

Intracellular binding of small-molecule phospho-Ags to the HMBPP receptor complex in infected cells leads to extracellular detection by T cells expressing the Vγ9Vδ2 TCR, a noncanonical method of Ag detection. The butyrophilin proteins BTN2A1 and BTN3A1 are part of the complex; however, their precise roles are unclear. We suspected that BTN2A1 and BTN3A1 form a tetrameric (dimer of dimers) structure, and we...

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Source

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Identifiers

PMID: 37171180
DOI: 10.4049/jimmunol.2200949
PMCID: PMC10330345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen-Bound BTN3A1.PMID 37171180Read ↗

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