Article
Keratinizing-type squamous cell carcinoma of the oropharynx: p16 overexpression is associated with positive high-risk HPV status and improved survival.
The American journal of surgical pathology - 1 Jun 2014
Cai Chunyu, Chernock Rebecca D, Pittman Meredith E, El-Mofty Samir K, Thorstad Wade L, Lewis James S
Abstract excerpt
It is well established that nonkeratinizing squamous cell carcinoma (SCC) of the oropharynx is causally related to transcriptionally active human papillomavirus (HPV) and has better survival as compared with carcinomas with a keratinizing phenotype (KSCC). Although the great majority of KSCCs are unrelated to HPV, transcriptionally active HPV is detected in a minority of oropharyngeal cases. To date, it has not...
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