Article
Molecular subclassification determined by human papillomavirus and epidermal growth factor receptor status is associated with the prognosis of oropharyngeal squamous cell carcinoma.
Human pathology - 1 Apr 2016
Nakano Takafumi, Yamamoto Hidetaka, Nakashima Torahiko, Nishijima Toshimitsu, Satoh Masanobu, Hatanaka Yui, Shiratsuchi Hideki, Yasumatsu Ryuji, Toh Satoshi, Komune Shizuo, Oda Yoshinao
Abstract excerpt
Human papillomavirus (HPV) infection is an indicator of good response to chemoradiotherapy in oropharyngeal squamous cell carcinoma (OPSCC), and epidermal growth factor receptor (EGFR) is a molecular-therapeutic target in head and neck squamous cell carcinoma. Here we investigated the prevalence and prognostic significance of HPV infection and EGFR alteration in OPSCC. We analyzed the presence of high-risk HPV...
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