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Article

Highly efficient multiplex targeted mutagenesis and genomic structure variation in Bombyx mori cells using CRISPR/Cas9.

Insect biochemistry and molecular biology - 1 Jun 2014

Liu Yuanyuan, Ma Sanyuan, Wang Xiaogang, Chang Jiasong, Gao Jie, Shi Run, Zhang Jianduo, Lu Wei, Liu Yue, Zhao Ping, Xia Qingyou

Abstract excerpt

Bombyx mori is an economically important insect and a model organism for studying lepidopteran and arthropod biology. Using a highly efficient CRISPR/Cas9 system, we showed that this system could mediate highly efficient targeted genome editing of a single gene locus, large chromosomal deletion or inversion, and also multiplex genome editing of 6 genes simultaneously in BmNs cell line derived from B. mori. The...

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PMID: 24698835
DOI: 10.1016/j.ibmb.2014.03.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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