Article
Tissue-specific genome editing of laminA/C in the posterior silk glands of Bombyx mori.
Journal of genetics and genomics = Yi chuan xue bao - 20 Sept 2017
Liu Yuanyuan, Ma Sanyuan, Chang Jiasong, Zhang Tong, Wang Xiaogang, Shi Run, Zhang Jianduo, Lu Wei, Liu Yue, Xia Qingyou
Abstract excerpt
The RNA-guided CRISPR/Cas9 system has been shown to be a powerful tool for genome editing in various organisms. A comprehensive toolbox for multiplex genome editing has been developed for the silkworm, Bombyx mori, a lepidopteran model insect of economic importance. However, as previous methods mainly relied on delivery of transient Cas9/guide RNA (gRNA), they could not be used in loss-of-function studies of...
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