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Article

CRISPR-Cas9-Mediated Mutation of Methyltransferase METTL4 Results in Embryonic Defects in Silkworm Bombyx mori.

International journal of molecular sciences - 9 Feb 2023

Guo Hao, Chen Feng, Zhou Mingyi, Lan Weiqun, Zhang Wenchang, Shen Guanwang, Lin Ping, Xia Qingyou, Zhao Ping, Li Zhiqing

Abstract excerpt

DNA N6-methyladenine (6mA) has recently been found to play regulatory roles in gene expression that links to various biological processes in eukaryotic species. The functional identification of 6mA methyltransferase will be important for understanding the underlying molecular mechanism of epigenetic 6mA methylation. It has been reported that the methyltransferase METTL4 can catalyze the methylation of 6mA;...

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PMID: 36834878
DOI: 10.3390/ijms24043468
PMCID: PMC9965800

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