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Article

Performance of random forest when SNPs are in linkage disequilibrium.

BMC bioinformatics - 5 Mar 2009

Meng Yan A, Yu Yi, Cupples L Adrienne, Farrer Lindsay A, Lunetta Kathryn L

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms (SNPs) may be correlated due to linkage disequilibrium (LD). Association studies look for both direct and indirect associations with disease loci. In a Random Forest (RF) analysis, correlation between a true risk SNP and SNPs in LD may lead to diminished variable importance for the true risk SNP. One approach to address this problem is to select SNPs in linkage...

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Identifiers

PMID: 19265542
DOI: 10.1186/1471-2105-10-78
PMCID: PMC2666661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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